Epithelialization during the proliferation phase is described as:

Epithelialization during the proliferation phase is described as:

• A. Migration of endothelial cells
• B. Resurfacing of the skin
• C. Deposition of type 3 collagen
• D. Expansion of granulation tissue

Answer: (B)

Epithelialization during the proliferative phase is about restoring the epidermal barrier by epithelial cells migrating to and covering the wound surface. In this phase, while granulation tissue forms and new blood vessels grow, the epidermis itself is rebuilt as keratinocytes move from the wound edges (and from any remaining follicles or sweat glands) across the moist wound bed. This resurfacing of the skin is what reestablishes the protective barrier, which is distinct from the formation of new tissue from endothelial cells (angiogenesis) or the deposition of collagen (the extracellular matrix, starting with type III) or overall expansion of granulation tissue. Hence, resurfacing of the skin best describes epithelialization.

Epithelialization during the proliferative phase is about restoring the epidermal barrier by epithelial cells migrating to and covering the wound surface. In this phase, while granulation tissue forms and new blood vessels grow, the epidermis itself is rebuilt as keratinocytes move from the wound edges (and from any remaining follicles or sweat glands) across the moist wound bed. This resurfacing of the skin is what reestablishes the protective barrier, which is distinct from the formation of new tissue from endothelial cells (angiogenesis) or the deposition of collagen (the extracellular matrix, starting with type III) or overall expansion of granulation tissue. Hence, resurfacing of the skin best describes epithelialization.